Dissecting uneven complex distribution

Dissecting complex polyketide biosynthesis

Numerous bioactive natural products are synthesised by modular polyketide synthases. These compounds can be made in high yield by native multienzyme assembly lines. However, formation of analogues by genetically engineered systems is often considerably less efficient. Biochemical studies on intact polyketide synthase proteins have amassed a body of knowledge that is substantial but still incomp...

Uneven distribution of light in standard phototherapy.

Maldistribution of light is a potential cause of phototherapy failure in the neonate. Differences in light intensity over the surface can be measured with a radiometer as this detects the radiant energy impinging on the incubator mattress. An infant nursed on the front third of the mattress receives less than 40% of the maximal light incident on the centre of the mattress, and consequently degr...

Dissecting complex epigenetic alterations in human lupus

Systemic lupus erythematosus is a chronic relapsing autoimmune disease that primarily afflicts women, and both a genetic predisposition and appropriate environmental exposures are required for lupus to develop and flare. The genetic requirement is evidenced by an increased concordance in identical twins and by the validation of at least 35 single-nucleotide polymorphisms predisposing patients t...

Evaluation of Classifiers for an Uneven Class Distribution Problem

Classification problems with uneven class distributions present several difficulties during the training as well as during the evaluation process of classifiers. A classification problem with such characteristics has resulted from a data-mining project where the objective was to predict customer insolvency. Using the dataset from the customer insolvency problem we study several alternative meth...

Airways obstruction and uneven gas distribution in the lung.